Understanding Collagen Supplements in Arthritis

 

Arthritis is derived from the Greek term “disease of the joints.” It is defined as an acute or chronic joint inflammation that often co-exists with pain and structural damage.

Osteoarthritis is characterized by a degenerative cascade of progressive cartilage loss which leads to bone damage.

Rheumatoid arthritis is a systemic and chronic inflammatory state caused by an autoimmune response to an environmental trigger. The degradation of cartilage and, eventually, bone is preceded by endothelial cell activation and synovial cell hyperplasia.

Scientifically rational approach to the three cornerstones of Arthritis management:

1. Symptomatic relief
   - With analgesic-anti-inflammatory medicines like NSAIDs

2. Reducing inflammatory cartilage damage
   - With Undenatured Collagen type II

3. Improving cartilage building
   - With Hydrolysed Collagen II and ECM-GAG

 

 

^aGALT , Gut-associated lymphoid tissue; ECM, Extracellular Matrix; GAG, Glycosaminoglycan

 

Reference:

1. Ma L, Cranney A, Holroyd-Leduc JM. Acute monoarthritis: what is the cause of my patient's painful swollen joint? 2009 Jan 06;180(1):59-65.
2. Struglics A, Larsson S, Kumahashi N, Frobell R, Lohmander LS. Changes in Cytokines and Aggrecan ARGS Neoepitope in Synovial Fluid and Serum and in C-Terminal Crosslinking Telopeptide of Type II Collagen and N-Terminal Crosslinking Telopeptide of Type I Collagen in Urine Over Five Years After Anterior Cruciate Ligament Rupture: An Exploratory Analysis in the Knee Anterior Cruciate Ligament, Nonsurgical Versus Surgical Treatment Trial. Arthritis Rheumatol. 2015 Jul;67(7):1816-25.
3. de Hair MJ, van de Sande MG, Ramwadhdoebe TH, Hansson M, Landewé R, van der Leij C, Maas M, Serre G, van Schaardenburg D, Klareskog L, Gerlag DM, van Baarsen LG, Tak PP. Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis. Arthritis Rheumatol. 2014 Mar;66(3):513-22. 
4. Narayanan V, Gandhi R.Understanding Collagen Supplements in Arthritis – Immunomodulation with Undenatured Collagen II Versus Cartilage Building with Hydrolysed Collagen II. Arch Orthop Rheumatol. 2019; 2(2): 04-11.